• If you are traveling on I-95, take I-40 West through Raleigh
• Continue on I-40 West toward Research Triangle Park
• Go north on Durham Freeway (Hwy 147)
• Exit on Chapel Hill St. (2nd exit after Durham Bulls Athletic Park)
• Turn right onto Chapel Hill St.
• Go straight as street changes name to Duke University Rd.
• Turn right on Towerview Rd. (2nd right after Chapel Dr.)
• Go through traffic circle and continue on Towerview to Science Dr.
• The Sanford Institute is on your left

From the West and Southwest (Atlanta, Charlotte, Greensboro via I-40 East and I-85 North)

• Take I-85 North when I-40 and I-85 fork
• Exit on Hwy 751 (It will say "To Duke University")
• Turn right onto Hwy 751 (Cameron Blvd.)
• Stay on 751 through a traffic circle, after which you will pass under 15-501 and cross Erwin Rd. (1st traffic light)
• Turn left on Science Dr. (2nd traffic light)
• The Sanford Institute is on your right at the first intersection (Towerview Rd.)

From the North (DC, Richmond via I-85 South)

• Take I-85 South into Durham
• Exit (on the right) onto 15-501 South
• Exit on Hwy 751 (Cameron Blvd.)
• Turn left onto Science Dr. (2nd traffic light)
• The Sanford Institute is on your right at the first intersection (Towerview Rd.)

From the South (Chapel Hill ) via 15-501

• North on US 15-501 toward Durham
• Take the 15-501 bypass (not Business 15-501, and not Martin Luther King Parkway)
• Exit on Hwy 751 (Cameron Blvd.), turn right.
• Turn left on Science Dr.
• The Sanford Institute is on your right at the first intersection (Towerview Rd.)