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The Danish 1905-Cohort Study (part of P01 AG008761, Project 2)
- Description of the Study
- The Questionnaire
- Description of the Data
- Data Use Agreement
- Publications
- Who to Contact
The Danish 1905-Cohort Study set out in 1998 to study all Danes born in 1905 who were invited to participate in a home-based, two hour, multidimensional interview, including cognitive and physical performance tests and the collection of DNA. The interview was carried out by lay interviewers using virtually the same instrument as in the Longitudinal Study of Aging Danish Twins (LSADT).
A total of 2262 individuals participated in the first wave in 1998, corresponding to a 63% participation rate. (Nybo et al., 2001a). Although the 63% participation rate in the Danish 1905-Cohort Study is lower than in LSADT, a comparison of non-responders and responders using registry information on hospitalizations and demographics indicates that the sample of participants was fairly representative. The follow-up survey in year 2000 of the Danish 1905-Cohort included a total of 1086 individuals corresponding to a 78% participation rate among the survivors.
The questionnaire includes questions on self-rated health, diseases, medicine, Activities of Daily Living (ADLs), cognitive abilities, depression, and life circumstances and events. Physical tests were included: grip strength, agility, speed, and spirometri. DNA samples were obtained through blood spots or cheek swabs. (For details see: Christensen K. Biological Material in Household Surveys. The Interface between Epidemiology and Genetics. In National Research Council "Cells and Surveys. Should Biological Measures Be Included in Social Science Research?" Committee on Population; Finch CE, Vaupel JW and Kinsella K (eds.). Commission on Behavioral and Social Sciences and Education. Washington DC, National Academy Press 2000: 42-63. [Download here])
English version of the 1998 questionnaire (PDF format)*.
The data are available on an individual leve. The data are available in SPSS format and will be delievered by Federal Express on 3.5" diskettes to interested users.
Due to the confidential nature of the data, it is expected that researchers interested in using the data will sign a Data Use Agreement (PDF format)*. To avoid double publication of the same data, proposals have to be specific and coordinated with other efforts within the project.
Publications from 1905-Cohort Study (see K. Christensen's website below for a full list.):
Christensen K, Johnson TE, Vaupel JW. The quest for genetic determinants of human longevity: challenges and insights. Nature Reviews Genetics 2006;7:436-448. Pubmed abstract
Hjelmborg J vB, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, Kaprio J, Pedersen NL, Christensen K. Genetic influence on human lifespan and longevity.Human Genetics 2006;119(3):312-321. Pubmed abstract
Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA, Kølvraa S, Christensen K. No association between telomere length and survival among the elderly and oldest-old. Epidemiology 2006;17(2):190-194. Pubmed abstract
Christiansen L, Brasch-Andersen C, Bathum L, Kruse TA, Christensen K. A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. Mechanisms of Ageing and Development 2006;127(7):597-599. Pubmed abstract
Hartvigsen J, Frederiksen H, Christensen K. Physical and mental function and incident low back pain in seniors. A population-based two-year prospective study of 1387 Danish twins aged 70 to 100 years. Spine 2006;31(14):1628-1632. Pubmed abstract
Graakjaer J, Londono-Vallejo JA, Christensen K, Kolvraa. The pattern of chromosome-specific variations in telomere length in humans shows sign of heritability and is maintained through life. Annals of the New York Academy of Sciences 2006;1067:311-6. Pubmed abstract
Sild M, Koca C, Bendixen MH, Frederiksen H, McGue M, Kolvraa S, Christensen K, Nexo B. Possible associations between successful aging and polymorphic markers in the Werner gene region. Annals of the New York Academy of Sciences 2006;1067:309-10. Pubmed abstract
Singh R, Kolvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI. Heat-schock protein 70 genes and human longevity: a view from Denmark. Annals of the New York Academy of Sciences 2006;1067:301-8. Pubmed abstract
Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, Christensen K. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biological Psychiatry 2006 [epub ahead of print] Pubmed abstract
Frederiksen H, Hjelmborg J, Mortensen J, McGue M, Vaupel JW, Christensen K. Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Annals of Epidemiology 2006 [epub ahead of print]. Pubmed abstract
Tan Q, Christiansen L, Bathum L, Li S, Kruse TA, Christensen K. Genetic associations analysis of human longevity in cohort studies of elderly subjects: an example of PON1 gene in the Danish 1905 birth cohort. Genetics 2006;172:1812-1828. Pubmed abstract
Tan Q, Kruse TA, Christensen K. Design and analysis in genetic studies of human ageing and longevity. Ageing Res Rev 2006.[Epub ahead of print]. Pubmed abstract
2005.
Rohr G, Stovring H, Christensen K, Gaist D, Nybo H, Kragstrup J. Characteristics of middle-aged and elderly women with urinary incontinence. Scand J Prim Health Care 2005;23(4):203-8. Pubmed abstract
Bathum L, Christiansen L, Tan Q, Vaupel J, Jeune B, Christensen K. No evidence for an association between extreme longevity and Microsomal Transfer Protein polymorphisms in a longitudinal study of 1651 nonagenarians. Eur J Hum Genet2005;13(10):1154-8 Pubmed abstract
Rexbye H, Petersen I, Iachina M, Mortensen J, McGue M, Vaupel JW, Christensen K. Hair loss among elderly men: etiology and impact on perceived age. Journal of Gerontology: Medical Sciences 2005;60A(8):1077-82. Pubmed abstract
Aviv A, Shay J, Christensen K, Wright W. The longevity gender gap: are telomeres the explanation? Sci Aging Knowledge Environ 2005;23:pe16. Pubmed abstract
Tan Q, Christiansen L, Bathum L, Zhao JH, Yashin AI, Vaupel JW, Christensen K, Kruse TA. Estimating haplotype relative risks on human survival in population-based association studies. Human Heredity 2005;59:88-97. Pubmed abstract
Poulsen P, Levin K, Petersen I, Christensen K, Beck-Nielsen H, Vaag A. Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes 2005;54(1):275-83. Pubmed abstract
Brakefield PM, Gems D, Cowen T, Christensen K et al. What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models? Mech ageing Dev. 2005;126:431-438. Pubmed abstract
2004.
Tan Q. Christiansen L, Bathum L, Zhao JH, Vach W, Vaupel JW, Christensen K, Kruse TA. Haplotype effects on human survival: logistic regression models applied to unphased genotype data.Annals of Human Genetics 2004;68:168-175 Pubmed abstract
De Maat MPM, Bladbjerg EM, Hjelmborg JvB, Bathum L, Jespersen J, Christensen K. Genetic influence on inflammation variables in the elderly. Arterioscler Thromb Vasc Biol 2004;24:2168-2173. Pubmed abstract
Christiansen L, Bathum L. Frederiksen H, Christensen K. Paraoxonase 1 polymorphisms and survival. European Journal of Human Genetics2004;12(10):843-47. Pubmed abstract
Rohr G, Christensen K, Ulstrup K, Kragstrup J. Reproducibility and validity of simple questions to identify urinary incontinence in elderly women. Acta Obstet Gynecol Scand 2004; 83: 969-72. Pubmed abstract
Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M, Christensen K. The catalase -262C/T promoter polymorphism and aging phenotypes. J Gerontol A Biol Sci Med Sci 2004;59(9):B886-9. Pubmed abstract
Tan Q, Christiansen L, Christensen K, Kruse TA, Bathum L. Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models. European Journal of Epidemiology 2004;19:651-656. Pubmed abstract
Tan Q, Yashin AI, Christensen K, Jeune B, De Benedictis G, Kruse TA, Vaupel JW. Multidisciplinary approaches in genetic studies of human aging and longevity. Current Genomics 2004;5:409-416.
Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kølvraa S, Christensen K, Londoño-Vallejo J-A. The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell 2004;3:97-102. Pubmed abstract
Christiansen L, Bathum L, Andersen-Ranberg K, Jeune B, Christensen K. Modest implication of interleukin-6 promoter polymorphisms in longevity. Mech Ageing Dev. 2004;125(5):391-5. Pubmed abstract
Tan Q, De Benedictis G, Yashin AI, Bathum L, Christiansen L, Dahlgaard J, Frizner N, Vach W, Vaupel JW, Christensen K, Kruse TA. Assessing genetic association with human survival at multi-allelic loci. Biogerontology 2004;4:89-97.
Andersen K, Nybo H, Gaist D, Petersen HC, McGue M, Jeune B, Vaupel JW, Christensen K. Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey. Dementia Geriatric Cognitive Disorders 2002;13(3):156-163.
Frederiksen H, McGue M, Jeune B, Gaist D, Nybo H, Skytthe A, Vaupel JW, Christensen K. Do children of long-lived parents age more successfully? Epidemiology 2002;13:334-339.
Bathum L, Christiansen L, Nybo H, Andersen-Ranberg K, Gaist D, Jeune B, Petersen NE, Vaupel JW, Christensen K. Association of mutations in the hemochromatosis gene with shorter life expectancy. Archives of Internal Medicine 2001;16:2441-2444
Nybo H, Gaist D, Jeune B, Bathum L, Vaupel JW, Christensen K. The Danish 1905-Cohort. A genetic-epidemiological nationwide survey. Journal of Aging and Health 2001;13(1):32-46.
Nybo H, Gaist D, Jeune B, McGue M, Vaupel JW, Christensen K. Functional status and self-rated health in 2,262 nonagenarians: the Danish 1905 Cohort Survey. Journal of the American Geriatrics Society 2001;49(5):601-609.
Christensen K. Biological Material in Household Surveys. The Interface between Epidemiology and Genetics. In National Research Council "Cells and Surveys. Should Biological Measures Be Included in Social Science Research?"
Committee on Population; Finch CE, Vaupel JW and Kinsella K (eds.). Commission on Behavioral and Social Sciences and Education. Washington DC, National Academy Press 2000: 42-63
For more information and to request the data, please contact:
Kaare Christensen, M.D., Ph.D. (email: KChristensen@health.sdu.dk)
Research Professor
Epidemiology
Institute of Public Health
University of Southern Denmark: Main Campus Odense University
Sdr. Boulevard 23A
DK-5000 Odense C, Denmark
Tel: + 45 65 50 30 49
Fax: + 45 65 90 69 38
.